You’ve worked hard to get your sample this far. Get the most from that precious material and hunt down the hidden information you couldn’t see before:
Proteoforms & peptide PTMs such as those with multiple phosphorylation sites
Intact mAb charge variants with online MS detection
Native protein conformation and interactions under native conditions
Isobaric metabolites and glycans not resolved by traditional techniques
Challenging charged & polar metabolites/degradation products such as anionic and/or hydrophilic analytes
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